// By the blinklab team

The Science Behind Blinklab

The rationale behind BlinkLab neurometric screening is supported by fundamental and clinical research by our team.  

Normal cognitive and social development require posterior cerebellar activity.
Badura A, (…), Wang SS-H (2018) Elife
Real-Time Face and Landmark Localization for Eyeblink Detection.

Bakker P, Boele HJ, Al-Ars Z, Strydis C (2020) Arxiv
Impaired Spatio-Temporal Predictive Motor Timing Associated with Spinocerebellar Ataxia Type 6.

Broersen R, (…), Boele HJ, (…), De Zeeuw CI (2016) PloS one

Cerebellar motor learning deficits in medicated and medication-free men with recent-onset schizophrenia.
Coesmans M, (…), Koekkoek SKE, De Zeeuw CI, (…) (2014)
J Psychiatry Neurosci
Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice.

De Vrij FMS, (…), Koekkoek SK, De Zeeuw CI, (…) (2008)
Neurobiol Dis
Modulation of 7 T fMRI Signal in the Cerebellar Cortex and Nuclei During Acquisition, Extinction, and Reacquisition of Conditioned Eyeblink Responses.
Ernst TM, (…), Boele H-J, Koekkoek SKE, (…), De Zeeuw CI, (…), (2017) Hum Brain Mapp
Cerebellar associative sensory learning defects in five mouse autism models.

Kloth AD, Badura A, (…), Wang SS-H (2015) Elife
Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile X syndrome.
Koekkoek SKE, De Zeeuw CI (2005) Neuron
Cerebellar function and ischemic brain lesions in migraine patients from the general population.
Koppen H, Boele HJ, Koekkoek SKE, (…), De Zeeuw CI (2017) Cephalalgia
Motor learning in children with neurofibromatosis type I.

Krab LC, (…), De Zeeuw CI, (…) (2011) Cerebellum

Performance in eyeblink conditioning is age and sex dependent.

Löwgren K, (…), Boele HJ, Koekkoek SKE, De Zeeuw CI, Hesslow G (2017) PLoS One
Spinocerebellar ataxia type 6 protein aggregates cause deficits in motor learning and cerebellar plasticity.
Mark MD, Boele HJ, Koekkoek SKE, De Zeeuw CI, (…) (2015) J Neurosci
Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice.
Peter S, (…), Boele HJ, (…), De Zeeuw CI (2016) Nat Commun

Savings and extinction of conditioned eyeblink responses in fragile X syndrome.
Smit AE, (…), Koekkoek SKE, (…), De Zeeuw CI, (…), (2008) Genes Brain Behav
Cerebellar cortex and cerebellar nuclei are concomitantly activated during eyeblink conditioning: a 7T fMRI study in humans.
Thurling M, (…), Boele HJ, De Zeeuw CI, (…), Koekkoek SK, (…), (2015) J Neurosci
Anti-malaria drug mefloquine induces motor learning deficits in humans.

Van Essen TA, (…), Koekkoek SKE, (…), De Zeeuw CI, (…), (2010) Front Neurosci
Contribution of CYLN2 and GTF2IRD1 to neurological and cognitive symptoms in Williams Syndrome.

Van Hagen JM, (…), Koekkoek SKE, (…), De Zeeuw CI (2007) Neurobiol Dis
Privacy-Preserving Object Detection & Localization Using Distributed Machine Learning: A Case Study of Infant Eyeblink Conditioning.
Zwaard S, Boele H-J, (…) (2020) arXiv:201007259

The cerebellum, sensitive periods, and autism.
Wang SS-H, Kloth AD, Badura A (2014) Neuron